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PAMAM Dendrimers
Poly(amido amine) (PAMAM) dendrimers represent an exciting new class of macromolecular architecture called "dense star" polymers. Unlike classical polymers, dendrimers have a high degree of molecular uniformity, narrow molecular weight distribution, specific size and shape characteristics, and a highly- functionalized terminal surface. The manufacturing process is a series of repetitive steps starting with a central initiator core. Each subsequent growth step represents a new "generation" of polymer with a larger molecular diameter, twice the number of reactive surface sites, and approximately double the molecular weight of the preceding generation.hol
Generation 2 PAMAM Dendrimer
The term "dendrimer" was derived from its tree-like branching structure. The table below shows the calculated properties* of amine surface functional PAMAM dendrimers by generation.
Generation |
Molecular Weight |
Measured Diameter (Å) |
Surface Groups |
0 |
517 |
15 |
4 |
1 |
1,430 |
22 |
8 |
2 |
3,256 |
29 |
16 |
3 |
6,909 |
36 |
32 |
4 |
14,215 |
45 |
64 |
5 |
28,826 |
54 |
128 |
6 |
58,048 |
67 |
256 |
7 |
116,493 |
81 |
512 |
8 |
233,383 |
97 |
1024 |
9 |
467,162 |
114 |
2048 |
10 |
934,720 |
135 |
4096 |
*Theoretical Properties, not to be used as specifications.
Click on the image below to see the step-growth
reaction of EDA to Generation 5 PAMAM Dendrimer
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