PAMAM Dendrimers

Polyamidoamine (PAMAM) dendrimers are hyperbranched polymers with unparalleled molecular uniformity, narrow molecular weight distribution, defined size and shape characteristics and a multifunctional terminal surface. These nanoscale polymers consist of an ethylenediamine core, a repetitive branching amidoamine internal structure and a primary amine terminal surface. Dendrimers are “grown” off a central core in an iterative manufacturing process, with each subsequent step representing a new “generation” of dendrimer. Increasing generations (molecular weight) produce larger molecular diameters, twice the number of reactive surface sites, and approximately double the molecular weight of the preceding generation. PAMAM dendrimers also assume a spheroidal, globular shape at Generation 4 and above (see molecular simulation below). Their functionality is readily tailored, and their uniformity, size and highly reactive “molecular Velcro” surfaces are the functional keys to their use.


Generation 2 PAMAM Dendrimer
(Click for larger view)

Dendrimer Terminal Group
(Click for larger view)

The term "dendrimer" was derived from its tree-like branching structure. The tables below show the calculated properties* of primary amine surface PAMAM dendrimers by generation, followed by common alternative surfaces. For mixed surfaces or other customized dendrimers, please inquire.

Generation

Molecular Weight

Measured Diameter (Å)

Surface Groups

0

517

15

4

1

1,430

22

8

2

3,256

29

16

3

6,909

36

32

4

14,215

45

64

5

28,826

54

128

6

58,048

67

256

7

116,493

81

512

8

233,383

 97

 1024

9

467,162

 114

 2048

10

934,720

 135

 4096


*Theoretical Properties, not to be used as specifications.

Generation

Molecular
Weight*

End Groups*

HYDROXY SURFACE PAMAM
PAMAM Dendrimer G2-OH
3272
16
PAMAM Dendrimer G3-OH
6941
32
PAMAM Dendrimer G4-OH
14279
64
PAMAM Dendrimer G5-OH
28954
128
PAMAM Dendrimer G6-OH 58304 256
PAMAM Dendrimer G7-OH 117005 512
     
SUCCINAMIC ACID SURFACE PAMAM    
PAMAM Dendrimer G2-SA Succinamic acid 4856 16
PAMAM Dendrimer G3-SA Succinamic acid 10109 32
PAMAM Dendrimer G4-SA Succinamic acid 20615 64
PAMAM Dendrimer G5-SA Succinamic acid 41626 128
PAMAM Dendrimer G6-SA Succinamic acid 83648 256
     
SODIUM CARBOXYLATE SURFACE PAMAM    
PAMAM Dendrimer G0.5 Caboxylate Sodium Salt 1269 8
PAMAM Dendrimer G1.5 Caboxylate Sodium Salt 2935 16
PAMAM Dendrimer G2.5 Caboxylate Sodium Salt 6267 32
PAMAM Dendrimer G3.5 Caboxylate Sodium Salt 12931 64
PAMAM Dendrimer G4.5 Caboxylate Sodium Salt 26258 128
PAMAM Dendrimer G5.5 Caboxylate Sodium Salt 52913 256
PAMAM Dendrimer G6.5 Caboxylate Sodium Salt 106222 512
PAMAM Dendrimer G7.5 Caboxylate Sodium Salt 212841 1024
     
HYDROPHOBE SUBSTITUTED PAMAM    
PAMAM Dendrimer G2-25% C12 Hydrophobe 4730 Mixed amine/hydrophobe
PAMAM Dendrimer G2-50% C12 Hydrophobe 6205 Mixed amine/hydrophobe
PAMAM Dendrimer G3-25% C12 Hydrophobe 9857 Mixed amine/hydrophobe
PAMAM Dendrimer G3-50% C12 Hydrophobe 12807 Mixed amine/hydrophobe
PAMAM Dendrimer G4-25% C12 Hydrophobe 20112 Mixed amine/hydrophobe
PAMAM Dendrimer G4-50% C12 Hydrophobe 26010 Mixed amine/hydrophobe
     


Note: Hydrophobe substituted is average molecular weight and average substitution; statistical distributions are obtained.


Below: The step-growth reaction of EDA to Generation 5 PAMAM Dendrimer